Harry Kane has been nominated for the PFA Player of the Year, while Dele Alli has is on the shortlist for the Young Player of the Year.
Kane is joined on the six-man shortlist by Alexis Sanchez, Zlatan Ibrahimovic, Remelu Lukaku and Chelsea pair N’Golo Kante and Eden Hazard.
The Spurs striker is the only English nominee in this category, and has netted 19 goals despite two spells out with ankle problems.
He was third in the voting last year and has also been shortlisted for the Young Player of the Year gong alongside Spurs team-mate Dele Alli.
Alli, who turned 21 on Tuesday, is also nominated for the Young Player of the year award which he won last year.
He has enjoyed another brilliant season, scoring 16 goals to help Mauricio Pochettino's side emerge as Chelsea's nearest challengers.
The Tottenham duo are joined by Lukaku, Burnley defender Michael Keane, Sunderland goalkeeper Jordan Pickford and Manchester City winger Leroy Sane.
Kante, who was shortlisted last year for his part in Leicester's remarkable season but did not make the top three, is the bookmakers' favourite for the 2016-17 accolade, with the winners to be announced at Grosvenor House in London on Sunday, April 23.
Hazard picked up this award two years ago, when the Blues won the league at a canter under Jose Mourinho.
Alexis Sanchez, Zlatan Ibrahimovic, Romelu Lukaku and Harry Kane also feature on the six-man shortlist, the PFA has announced.
Everton forward Lukaku, the top flight's leading scorer this term with 23 goals, is battling it out with a number of his fellow nominees for the Golden Boot.
Manchester United striker Ibrahimovic has scored 17 goals in his first season in English football, while Sanchez has notched 18 times to brighten up what has been a disappointing campaign for Arsenal.
Keane's impressive form for the Clarets this term earned him a first England senior call-up late last year, and he now has two caps to his name. Pickford has performed well between the posts in a struggling Black Cats side, while Germany international Sane has won rave reviews of late following his big-money summer arrival from Schalke.